Thursday, October 23, 2008

Miracle Mud

On Thursday, our department lecture series brought Dr. Lynda Williams of Arizona State University to talk about antibacterial clays. Now, mineralogy was never my strong point, but this talk brought a whole new perspective to it - that mineralogy can contribute to medical research!

For a little background: There's a kind of mycobacteria (yep, that's spelled right) that exists in African swamps that gets onto the pincers of a biting waterbug. When people are bitten, the bacteria gets under their skin and creates an infection, which eventually (WARNING - ICKY PART) causes their skin to rot and slough off. It's basically a flesh-eating bug, like necrotizing fasciitis, and in the past, the only real treatment has been to amputate the affected limb. It's called Buruli ulcer, and it's nasty, and the people who get it don't do well. If they survive the infection and don't have the limb amputated, they have to have extensive and messy skin grafts to repair what are essentially open wounds.

One woman, however - a French humanitarian treating people in the Ivory Coast,
Madame Line Brunet de Courssou - heard about special French green clays that were purported to have antibacterial properties. This is a claim that's been put forward by a lot of alternative medical people, and there are literally thousands of places on the internet and elsewhere that you can order healing muds. But Madame de Courssou remembered using the clay to heal cuts and burns when she was a child, and wanted to try it out on the people she was treating for Buruli ulcer. Incredibly, she discovered that the clay not only killed the infection, but helped skin grow back over the wounds. The treatment was both effective and cheap, which made it extremely valuable for people who had no way to afford expensive and difficult-to-obtain drugs, and naturally she wanted to bring it to people's attention. When she tried to get support for her treatments from the World Health Organization, though, she met with a great deal of criticism to the effect that her claims were not scientifically supported. So...

Dr. Lynda Williams comes in. She's a clay mineral geochemist, and was asked to help figure out just what about the green clays stops infections. I can't possibly do her talk justice here, but I can remember a few of the highlights: It seems that the antibacterial properties of the clays - which are mostly smectites - are linked not only to a specific size fraction of the clay minerals (~200 nanometers), but to trace minerals in the clays. She went through a complicated process of testing clays with interstitial water removed, and leached clay, and pH-adjusted clay; it turns out that in the French clays, the presence of iron had something to do with the antibacterial properties. (The clay leachates, which must have contained some iron, also killed bacteria, although they weren't effective after a certain time span. I think that Dr. Williams suggested that this might have something to do with the oxidation process the iron is undergoing - there was an Eh-pH diagram involved at one point.)

Not only do the French clays seem to kill Buruli ulcer, they also go after things like E. Coli and staph - with amazing results. One of the clay samples killed 100% of the E. Coli, and most of a particularly resistant staph strain. And these aren't the only clays that do this - some clay samples Dr. Williams received from undisclosed locations in the US do the same thing. (They have somewhat different chemical properties, however, which makes the puzzle even harder to piece together.) At any rate, she and her colleagues are still examining the clays, doing various kinds of geochemical analysis and SEM/TEM imaging to try and figure out the specific factor - or combination thereof - that makes them valuable as antibacterial agents.

And the best part? The clays are derived from altered volcanic rocks. That's right - volcanoes are saving lives! (Well, really indirectly and a long time after the fact.)*

I don't know about you all, but if I ever get a staph infection from a hospital visit, I'm definitely asking for a mud bath.

Read more:

*Believe me, I can find volcanology anywhere.


helena.heliotrope said...

I'm never going to do a mud mask again without thinking about flesh eating bacteria. YES.
So, I've been lurking about your blog for a bit, but I now have a question worth asking (if you don't mind my asking): when choosing your graduate program, how did you find out which school was the best? They all purport to be fantastic in their field, but how does one actually tell? I'm trying to find a good undergraduate program in geology (specifically: volcanology) so I reckoned you might know what to look for.
Anyway, thanks for letting me take a minute of your time, and good luck with your program :)

Tuff Cookie said...

Welcome to the blog! As for programs, the best way to get a feel for where you'll fit is to go visit, although I know that's not always possible if you're just starting off. (I'll go through my process of grad school searching for you, though, since I'm not sure what point you're at.)

If you're just starting, the USGS Cascades Volcano Observatory has a good list of schools that have programs in volcanology. This doesn't cover all of them, but it's a start.

If you're poking around on websites, start looking at what areas of volcanology the faculty specialize in. If you're not interested in a specific thing, see if the classes and research covers a broad range of topics - this means you'll have a lot to choose from. Start emailing professors - tell them about your experience and ask about their work. Most will be happy to talk about it, and to give you their observations about their programs.

If you have a chance to go to any professional meetings (especially AGU), talk to the grad school representatives AND find out if anyone you might want to work with is presenting. Go to their talks and introduce yourself, if you have the chance.

Once you've established contacts, the next step is to visit. This is the most important part - I was really interested in several programs, but realized that I wouldn't be happy in the departments themselves, for various reasons. Likewise, I ended up going to a place that wasn't necessarily the most appealing in terms of location or the campus, but which has a great program full of smart people that I want to work with. What's most important is who you feel comfortable around, and that means visiting.

If you want, I'd be happy to give you my impressions of the schools that I've visited, and a few more that I researched.

Anonymous said...

Only anecdotal, I know, but I was on a geological tour of the Greek islands several years ago. I got an echinoid spine in my finger and the wound went septic and wouldn't clear up. I went to Santorini and took a boat tour to the new volcanic cone (Nea Kameni) rising up from the floor of the old caldera. Part of the trip involved a swimming stop where volcanic springs rose from the sea bed and made the water very warm. The sea bottom comprised thick sticky mud and (being with a group of geologists) a mud fight ensued. Next day, however, my finger had completely healed. The locals claimed healing properties for the mud too.

BrianR said...

Tuff Cookie gives sound advice ... also, try e-mailing grad students and ask their opinions ... I got some good feedback when I tried that when looking for a PhD program.